Bioethics of preclinical research in biomedical sciences

Authors

  • Denia Morales Navarro Universidad de Ciencias Médicas de La Habana. Facultad de Estomatología "Raúl González Sánchez"

Keywords:

bioethics, ethics of animal research, animal welfare, animal ethics committees, pain, euthanasia, alternatives to laboratory animals.

Abstract

Introduction: opposition to the use of animals in biomedical research is based on a variety of scientific and ethical arguments.
Objective: carry out a bibliographic review about the bioethics of preclinical research in biomedical sciences.
Data collection procedures: an online search was conducted for papers preferably published in the last five years. An evaluation was performed of international high impact journals from the Web of Sciences which dealt with the subject (38 journals). Databases from reference systems such as MEDLINE, PubMed and SciELO were consulted with the aid of search terms like "animal research" "ethical", "animal welfare", " animal ethics committee", "animal pain", "alternatives to laboratory animals" and their Spanish counterparts. The papers included were in English, Portuguese or Spanish. Of the 141 papers obtained, the reviewers selected the 53 which approached the study topic in a more comprehensive manner.
Analysis and integration of information: an analysis of the representativeness of papers in the scientific journals where they were published showed that 5.9 % corresponded to the journal Alternatives to Laboratory Animals: ATLA, and an equal percentage to the journal Cambridge Quarterly of Healthcare Ethics. The remaining papers were evenly distributed among the other journals.
Conclusions: awareness of and compliance with the bioethical principles governing the behavior of human beings and their relationship to the environment and fields of knowledge, enable a generalizing approach to and comprehensive management of significant aspects of animal research.

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Author Biography

Denia Morales Navarro, Universidad de Ciencias Médicas de La Habana. Facultad de Estomatología "Raúl González Sánchez"

Especialista de segundo grado en Cirugía Maxilofacial

Asistente de la Facultad de Estomatología UCMH

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Published

2015-06-28

How to Cite

1.
Morales Navarro D. Bioethics of preclinical research in biomedical sciences. Rev Cubana Estomatol [Internet]. 2015 Jun. 28 [cited 2025 Jun. 6];52(4):39-51. Available from: https://revestomatologia.sld.cu/index.php/est/article/view/475

Issue

Vol. 52 No. 4 (2015): OCT- DEC

Section

Review Article

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