Effect of the non-quirurgical periodontal treatment over the endotelial function
Keywords:
Endothelium, Periodontitis, Blood Vessels.Abstract
Introduction: Periodontitis is characterized by being an inflammation mediated by the host and associated with microbes that produce, the loss of periodontal adhesion. A localized focal infection such as periodontal disease could lead to systemic inflammation. Vascular endothelial dysfunction has been associated with a variety of pathologies and risk factors for atherosclerosis, including age, hypertension, dyslipidemias, diabetes, smoking, specific cardiovascular pathologies such as coronary artery disease, cerebral, inflammatory, and infectious processes such as periodontal disease. Objective: Assess the effects of non-surgical periodontal treatment on the endothelial function of patients with chronic periodontitis through a review of randomized clinical trials. Methods: We used a primary search strategy using a combination of controlled vocabulary and free text terms based on the MEDLINE search strategy through PubMed using the PubMed Advanced Search Builder on July 05, 2019. Analysis and integration of the information: 29 articles of 2214 were selected because they are human studies where the study variables are related. 100% of the selected articles found that 37.9% belonged to case-control studies, 31% belonged to cross-sectional studies, 10.34% to cohort studies and only 20.6% were clinical trial studies, of which only 3 articles (10%) were selected for this review. Conclusions: Periodontal therapy does not have an effect on endothelial function in a period of 3 months, however at 6 months an improvement in endothelial function was reported.
Downloads
References
Tonetti MS, Greenwell H, Kornman KS. Staging and grading of periodontitis: Framework and proposal of a new classification and case definition. J Periodontol. 2018;89(1):159-72.
Slots J. Periodontitis: facts, fallacies and the future. Periodontol 2000. 2017;75(1):7-23.
Punj A, Shenoy SB, Subramanyam K. Comparison of Endothelial Function in Healthy Patients and Patients with Chronic Periodontitis and Myocardial Infarction. J Periodontol. 2017;88(12):1234-43.
Nicolosi LN, Lewin PG, Rudzinski JJ, Pompeo M, Guanca F, Rodríguez P, et al. Relation between periodontal disease and arterial stiffness. J Periodontal Res. 2017;52(1):122-6.
Konukoglu D, Uzun H. Endothelial Dysfunction and Hypertension. Adv Exp Med Biol. 2017;956:511-40.
Saffi MAL, Rabelo-Silva ER, Polanczyk CA, Furtado MV, Montenegro MM, Ribeiro IWJ, et al. Periodontal therapy and endothelial function in coronary artery disease: A randomized controlled trial. Oral Dis. 2018;24(7):1349-57.
Bia D, Zócalo Y. Función endotelial y reactividad macro y microvascular: evaluación no invasiva en la práctica clínica Importancia clínica y análisis de las bases metodológicas de los equipos disponibles para su evaluación. Rev Urug Cardiol 2014;29(3):351-68.
Orlandi M, Suvan J, Petrie A, Donos N, Masi S, Hingorani A, et al. Association between periodontal disease and its treatment, flow-mediated dilatation and carotid intima-media thickness: a systematic review and meta-analysis. Atherosclerosis 2014;236(1):39-46.
Tonetti MS, D'Aiuto F, Nibali L, Donald A, Storry C, Parkar M, et al. Treatment of periodontitis and endothelialfunction. N Engl J Med. 2007;1;356(9):911-20.
Saffi MAL, Rabelo-Silva ER, Polanczyk CA, Furtado MV, Montenegro MM, Ribeiro IWJ, et al. Periodontal therapy and endothelial function in coronary artery disease: A randomized controlled trial. Oral Dis. 2018;24(7):1349-57.
Li X, Tse HF, Yiu KH, Li LS, Jin L. Effect of periodontal treatment on circulating CD34 (+) cells and peripheral vascular endothelial function: a randomized controlled trial. J Clin Periodontol. 2011;38(2):148-56.
Higgins JPT, Green S (Eds.). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0 [actualizado: 03/2011]. The Cochrane Collaboration. 2011 [acceso: 05/07/2019]. Disponible en: https://handbook-5-1.cochrane.org/
Papapanou PN, Sanz M, Budunelli N, Dietrich T, Feres M, Fine D, et al. Periodontitis: Consensus report of workgroup 2 of the 2017 World Workshop on the Classification of Periodontal and Peri‐Implant Diseases and Conditions. J Clin Periodontol. 2018;45 (Suppl 20):S162–S170.
Godo S, Shimokawa H. Endothelial Functions. Arterioscler Thromb Vasc Biol. 2017;37(9):108-114.
Castro-Ferreira R, Cardoso R, Leite-Moreira A, Mansilha A. The Role of Endothelial Dysfunction and Inflammation in Chronic Venous Disease. Ann Vasc Surg. 2018;46:380-93.
Gurav AN. The implication of periodontitis in vascular endothelial dysfunction. Eur J Clin Invest. 2014;44(10):1000-9.
Falcao A, Bullón P. A review of the influence of periodontal treatment in systemic diseases. Periodontol 2000. 2019;79(1):117-28.
Johansson A, Claesson R, Lindholm M, Höglund Aberg C, Oscarsson J. The role of Aggregatibacter actinomycetemcomitans and its leukotoxin in periodontitis. J Oral Microbiol. 2017;9(sup1):1325203.
Teeuw WJ, Slot DE, Susanto H, Gerdes V, Abbas F, D'Aiuto F, et al. Treatment of periodontitis improves the atherosclerotic profile: a systematic review and meta-analysis. J Clin Periodontol. 2014;41(1):70-79.
Olchanheski LR Jr, Sordi R, Oliveira JG, Alves GF, Mendes RT, Santos FA, et al. The role of potassium channels in the endothelial dysfunctioninduced by periodontitis. J Appl Oral Sci. 2018;4:1-10.
Moura MF, Navarro TP, Silva TA, Cota LOM, Soares Dutra Oliveira AM, Costa FO. Periodontitis and Endothelial Dysfunction: Periodontal Clinical Parameters and Levels of Salivary Markers Interleukin-1β, Tumor Necrosis Factor-α, Matrix Metalloproteinase-2, Tissue Inhibitor of Metalloproteinases-2 Complex, and Nitric Oxide. J Periodontol. 2017;88(8):778-87.
Dietmann A, Millonig A, Combes V, Couraud PO, Kachlany SC, Grau GE. Effects of Aggregatibacter actinomycetemcomitans leukotoxin on endothelial cells. Microb Pathog. 2013;61-62(100):43-50.
Leira Y, Rodríguez-Yáñez M, Arias S, López-Dequidt I, Campos F, Sobrino T, et al. Periodontitis is associated with systemic inflammation and vascular endothelial dysfunction in patients with lacunar infarct. J Periodontol. 2019;90(5):465-74.
Downloads
Published
How to Cite
Issue
Section
License
Authors retain all rights to their works, which they can reproduce and distribute as long as they cite the primary source of publication.
The Rev Cubana Estomatol is subject to the Creative Commons Attribution-Non-Commercial 4.0 International License (CC BY-NC 4.0) and follows the publication model of SciELO Publishing Schema (SciELO PS) for publication in XML format.
You are free to:
- Share — copy and redistribute the material in any medium or format.
- Adapt — remix, transform, and build upon the material.
The licensor cannot revoke these freedoms as long as you follow the license terms.
Under the following terms:
Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
- NonCommercial — You may not use the material for commercial purposes.
No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
Notices:
- You do not have to comply with the license for elements of the material in the public domain or where your use is permitted by an applicable exception or limitation.
- No warranties are given. The license may not give you all of the permissions necessary for your intended use. For example, other rights such as publicity, privacy, or moral rights may limit how you use the material.