Periodontitis, Porphyromonas gingivalis and its relation to quorum sensing expression

Authors

  • Antonio Díaz Caballero Facultad de Odontología. Universidad de Cartagena
  • Ricardo Vivas Reyes Facultad de Ciencias Exactas y Naturales. Universidad de Cartagena
  • Leonardo Puerta Llerena Instituto de Investigaciones Inmunológicas. Facultad de Medicina. Universidad de Cartagena
  • Maicol Ahumedo Monterrosa Facultad de Ciencias Exactas y Naturales. Universidad de Cartagena
  • Ricardo Cabrales Salgado Facultad de Odontología. Universidad de Cartagena
  • Alejandra Herrera Herrera Facultad de Odontología. Universidad de Cartagena
  • Miguel Simancas Pallares Facultad de Odontología. Universidad de Cartagena

Keywords:

periodontitis, porphyromonas gingivalis, biofilms, quorum sensing.

Abstract

The bacterial signaling mechanisms play a key role in the establishment and
progression of periodontal disease. Due to these circumstances it is crucial to
deepen in the understanding of these mechanisms to try to provide novel
therapeutic strategies. The objective of present narrative literature review was to
make a critical analyze of the available evidence on the influence of Porphyromonas
gingivalis (PG) and the quorum sensing expression in periodontal disease. Using the
Ovid (MEDLINE) ScienceDirect, Hinari database we made a search. The current
knowledge of these mechanisms offers the possibility of developing new and deep
studies (theoretical and experimental) on the QS expression in patients presenting
with periodontal disease allowing a novel research field not currently available.
From its discovery the QS is discerned as a valuable research space in which we
must to insist in a permanent way. The above mentioned evidence allows
concluding that by the regulation of the expression of determined genes in bacteria
like PG, it is possible to carry out the inhibition in the formation of the biofilms with
direct and indirect effects on the periodontal disease development.

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Published

2010-10-18

How to Cite

1.
Díaz Caballero A, Vivas Reyes R, Puerta Llerena L, Ahumedo Monterrosa M, Cabrales Salgado R, Herrera Herrera A, et al. Periodontitis, Porphyromonas gingivalis and its relation to quorum sensing expression. Rev Cubana Estomatol [Internet]. 2010 Oct. 18 [cited 2025 Mar. 13];47(4):404-16. Available from: https://revestomatologia.sld.cu/index.php/est/article/view/2682

Issue

Vol. 47 No. 4 (2010): OCT- DEC

Section

Review Article

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