Proteolytic enzymes related to inflammatory periodontal disease
Abstract
Inflammatory periodontal disease causes the destruction of the tissues that protect and support the tooth; It is therefore of great importance the role that enzymes can play that are capable of degrading the connective tissue matrix, such as proteolytic enzymes. There is evidence that matrix metalloproteinases, leukocytic proteases and bacterial proteases can participate in the etiopathogenesis of this disease. Its action is regulated in the tissues, by the presence of specific inhibitors, so that an unbalanced protease inhibitor in favor of the former, would lead to the destruction of the connective tissue matrix proteins. In turn, in the proteolytic activity influence different factors, that globally, induce a degradative or formative phenotype, and that therefore, could be involved in the etiopathogenesis of inflammatory periodontal disease.Downloads
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