Neurons involved in the sensory modality of orofacial pain from periphery to encephalon
Keywords:
nociception, high threshold ion channels, pseudounipolar nociceptors.Abstract
Introduction: Pain from the head and neck is linked to the trigeminal pathway and three neurons participate: a first-order neuron located in the trigeminal ganglion, a second-order neuron from the subnucleus caudalis of the trigeminal nerve, and a third-order neuron which starts from the medial area of the ventrobasal thalamus complex and ends in the cerebral cortex.
Objective: Describe the way in which a chain of neurons transmit tissue damage to the encephalon by means of nerve impulses.
Content: In first-order neurons, their neuronal bodies are located in the trigeminal spinal ganglion, in temporal bone. In the subnucleus caudalis, second-order neurons are found which receive nociceptive and temperature stimuli from the face and mouth. Their axons cross over the extension of this subnucleus, ascend contralaterally and establish synapses with third-order neurons in the thalamus. In the encephalon there is not a single "pain center": third-order neurons end in different areas of the cerebral cortex recognized as the "pain matrix".
Final considerations: Three sets of neurons make up the trigeminal nociceptive pathway. The first one is located in the trigeminal ganglion outside the central nervous system whereas the other two form nuclei within it.Downloads
References
Guyton AC, Hall JE. Tratado de Fisiología Médica. 13ra. ed. México: McGraw-Hill. Interamericana Editores, SA, de C.V; 2016.
Ganong WF. Fisiología médica. 25ta. ed. México: El Manual Moderno, S.A. de C.V; 2016.
González Roldán AM. Dinámica de la actividad cerebral asociada al procesamiento de estímulos nociceptivos y afectivos en pacientes con dolor crónico [Tesis doctoral en Internet]. Palma, España: Universitat de les Illes Balears; 2013 [acceso 15/07/2019]. Disponible en: http://dspace.uib.es/xmlui/bitstream/handle/11201/2648/Gonzalez_Roldan_AnaMaria.pdf?sequence=1&isAllowed=y
Pérez Ruíz AO. El Estomatólogo y su relación con el dolor y la sangre. 2da. ed. La Habana: Editorial Ciencias Médicas; 2019.
Barayón Irrazabal MI, Bucarey Fuenzalida MI. Fisiología del dolor: Canales de potencial, transitorio (trp) en la pulpa dental [Tesis doctoral en Internet]. Santiago, Chile: Universidad Finis Terrae; 2017 [acceso 09/11/2019]. Disponible en: http://repositorio.uft.cl/bitstream/handle/20.500.12254/557/BARAYON-BUCAREY%202017.pdf?sequence=1&isAllowed=y
Santos-Velázquez T. Neuralgia del trigémino idiopática. Revista Electrónica Dr. Zoilo E. Marinello Vidaurreta [Internet]. 2019 Ene-feb [acceso 06/06/2019];44(1):[aprox. 10 p.]. Disponible en: http://revzoilomarinello.sld.cu/index.php/zmv/article/download/1668/pdf_548
Cotran RS, Kumar V, Collins T. Patología Estructural y Funcional. 9na. ed. España: McGraw-Hill. Interamericana S.A.U; 2015.
De Byers M, Bonica J. Peripheral pain mechanisms and nociceptor plasticity. En: Loeser J, ed. Bonica's management of pain. 3ra. ed. Philadelphia: Lippincott Williams & Williams; 2001. p. 38-9.
Jiménez Murillo L, Montero Pérez FJ. Compendio de Medicina de Urgencias: guía
terapéutica. 5ta. ed. Madrid: Editorial Elsivier; 2015.
Morfofisiología. Tomo II. 2da. ed. La Habana: Editorial Ciencias Médicas; 2015.
Komabayashi T, Zhu Q. Innovative endodontic therapy for anti-inflammatory direct pulp capping of permanent teeth with a mature apex. Oral Surg Oral Med Oral Pathol Oral Radiol Endod [Internet]. 2010 [acceso 12/06/2017];19(5):75-81. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2862994/pdf/nihms-168095.pdf
Nadkarni MA, Simonian MR, Harty DW, Zoelner H, Jacques NA, Hunter N. Lactobacilli Are Prominent in the Initial Stages of Polymicrobial Infection of Dental Pulp. J Clin Microbiol [Internet]. 2010 [acceso 12/06/2017];48(5):1732-40. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2863874/pdf/1912-09.pdf
Niazi SA, Clarke D, Do T, Steven C, Mannocci GF, Beighton D. Propionibacterium acnes and Staphylococcus epidermidis Isolated from Refractory Endodontic Lesions Are Opportunistic Pathogens. J Clin Microbiol [Internet]. 2010 [acceso 29/11/2019];48(11):3859-69. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3020818/pdf/1326-10.pdf
Petti S, Glendor U, Andersson L. World traumatic dental injury prevalence and incidence, a meta-analysis-One billion living people have had traumatic dental injuries. Dent Traumatol [Internet]. 2018 Apr [acceso 29/11/2019];34(2):71-86. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/29455471
Aguirre-Siancas E, Seclén-Ubillús Y, Ruiz-Ramírez E, Portilla-Flores O, Crispín-Huamani L, Alarcón-Velásquez L, et al. Influencia del estrés crónico y de la masticación sobre el dolor. Rev Ecuat Neurol [Internet]. 2019 May-ago [acceso 29/11/2019];28(2):[aprox. 16 p.]. Disponible en: http://revecuatneurol.com/magazine_issue_article/influencia-estres-cronico-masticacion-sobre-dolor-influence-chronic-stress-chewing-over-pain/
Delfín Soto O, Delfín O. Perpetuación del dolor en lesiones severas y persistentes. En: Congreso Internacional de Estomatología; 2015 Nov 2-6; La Habana, Cuba. La Habana: Palacios de las Convenciones; 2015 [acceso 29/11/2019]. Disponible en: http://www.estomatologia2015.sld.cu/index.php/estomatologia/nov2015/paper/view/141/83
de Melo Júnior PC, Aroucha JMCNL, Arnaud M, Lima MGS, Gomes SGF, Ximenes R, et al. Prevalence of TMD and level of chronic pain in a group of Brazilian adolescents. Plos One [Internet]. 2019 Feb 8 2019 [acceso 29/11/2019];14(2):[aprox. 28 p.]. Disponible en: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0205874
Prades JM, Gavid M. Dolor en otorrinolaringología. EMC- Otorrinolaringología [Internet]. 2018 Feb [acceso 29/07/2019];47(1):1-19. Disponible en: https://www.sciencedirect.com/science/article/pii/S1632347517878851
Portilla-Flores O, Crispín-Huamani L, Aguirre-Siancas E, Seclén-Ubillús Y, Ruiz-Ramírez E, Alarcón-Velásquez L, et al. Influencia del estrés crónico y de la masticación sobre el dolor. Rev Ecuat Neurol [Internet]. 2019 Ago [acceso 02/12/2019];28(2):13-8. Disponible en: http://scielo.senescyt.gob.ec/scielo.php?script=sci_arttext&pid=S2631-25812019000200013&lng=es.
Melzack R. Pain and the neuromatrix in the brain. Journal Dental Education [Internet]. 2001 [acceso 29/11/2019];65:1378-82. Disponible en: https://www.ncbi.nlm.nih.gov/pubmed/11780656
França Correia LM, Hummig W, Adamowicz T, de Almeida DB. A importância da avaliação da presença de disfunção temporomandibular em pacientes com dor crónica. Rev dor São Paulo [Internet]. 2014 Jan-Mar [acceso 08/03/2017];15(1):6-8. Disponible en: http://www.scielo.br/pdf/rdor/v15n1/1806-0013-rdor-15-01-0006.pdf
Campos Fabri GM, Savioli C, Tesseroli Siqueira JT. Tratamiento Periodontal y Calidad de Vida en Pacientes con Dolor Facial Crónico. Int J Odontostomat [Internet]. 2014 Sep [acceso 08/03/2017];8(2):247-52. Disponible en: https://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0718-381X2014000200017&lng=es
Palomino Peña J. Prevalencia de celulitis en el Servicio de Pediatría del Hospital María Auxiliadora desde el año 2009- año 2014 [Tesis en Internet]. Lima, Perú: Universidad Ricardo Palma; 2016 [acceso 29/11/2019]. Disponible en: http://repositorio.urp.edu.pe/bitstream/handle/urp/574/Palomino_j.pdf?sequence=1&isAllowed=y
Florencio LL, De Oliveira AS, Carvalho GF, Dach F, Bigal ME, Fernández-de-las-Peñas C, et al. Dolor temporomandibular y la frecuencia de episodios de migraña. J Manipulative Physiol Ther [Internet]. 2017 [acceso 29/11/2019];40:250-4. Disponible en: https://www.neurologia.com/noticia/6495/asocian-el-dolor-temporomandibular-con-la-frecuencia-de-episodios-de-migrana
García Olea A. Ensayo clínico controlado: Docencia en neurolobiología de dolor crónico como tratamiento coadyuvante en pacientes con migraña e indicación de tratamiento preventivo [Tesis en Internet]. Leioa, España: Facultad de Medicina y Enfermería; 2018 [citado 15 Jul 2019]. Disponible en: https://addi.ehu.es/bitstream/handle/10810/30827/TFG_Garcia_Olea_Rev.pdf?sequence=1&isAllowed=y
Torrecillas-Martíneza L, Catenab A, O’Vallec F, Padial-Molinad M, Galindo-Moreno P. Does experienced pain affects local brain volumes? Insights from a clinical acute pain model. International Journal of Clinical and Health Psychology [Internet]. 2019 May [acceso 15/07/2019];19(2):115-23. Disponible en: https://www.elsevier.es/en-revista-international-journal-clinical-health-psychology-355-articulo-does-experienced-pain-affects-local-S1697260018301406
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