Risk factors for oral cancer

Authors

  • Pedro Antonio Miguel Cruz Clínica Estomatológica Manuel Angulo. Holguín
  • Aluett Niño Peña Departamento de Estomatología. Facultad de Ciencias Médicas "Mariana Grajales Coello". Universidad de Ciencias Médicas. Holguín
  • Kelia Batista Marrero Departamento de Estomatología. Facultad de Ciencias Médicas "Mariana Grajales Coello". Universidad de Ciencias Médicas. Holguín
  • Pedro Enrique Miguel-Soca Departamento de Ciencias Básicas. Facultad de Ciencias Médicas "Mariana Grajales Coello". Universidad de Ciencias Médicas. Holguín

Keywords:

oral cancer, risk factors, oncogenes, tumor suppressor genes, tobacco, alcohol, prevention.

Abstract

Introduction: oral cancer is a disease with high morbidity and mortality, associated with risk factors whose complex interplay is subject to scientific debate.
Objective: to upgrade to the professionals about the risk factors for oral cancer.
Methods: the literature review was conducted in SciELO Regional with the descriptors "risk factors" and "oral cancer", for which 31 full-text references were found. In Clinical Key, with the descriptor "cancer of the lip and oral cavity", we found 1746; English descriptors with "genes" and "oral cancer" retrieved 9822 results. PubMed, with the descriptor "oral cancer", retrieved 1207 items. EBSCO, with the descriptor "oral cancer", offered full texts of 5 recent years (839 articles). 200 articles in English and Spanish were retrieved, mainly from 2010-2015, and 62 papers were used.
Data analysis and integration: in the oral carcinogenesis, tumor suppressor genes and oncogenes are affected. The non-genetic risk factors are smoking, alcohol consumption, and nutrient deficiency states, environmental factors such as radiation and heavy metals and different bacterial, fungal and viral infections. These factors are also related to immunosuppression, mechanical friction by maladjusted dentures and poor oral hygiene.
Conclusions: the main risk factors for oral cancer are described. Susceptibility genes to cancer interact with risk factors mainly related to lifestyle and environmental factors in a complex network, whose identification and control in primary health care is important in the prevention of oral cancer by dentists.

Key words: oral cancer; risk factors; oncogenes; tumor suppressor genes; tobacco; alcohol; prevention.

Downloads

Download data is not yet available.

Downloads

Published

2016-08-29

How to Cite

1.
Miguel Cruz PA, Niño Peña A, Batista Marrero K, Miguel-Soca PE. Risk factors for oral cancer. Rev Cubana Estomatol [Internet]. 2016 Aug. 29 [cited 2025 Feb. 12];53(3):29-36. Available from: https://revestomatologia.sld.cu/index.php/est/article/view/1030

Issue

Vol. 53 No. 3 (2016): JUL- SEP

Section

Review Article

License

Authors retain all rights to their works, which they can reproduce and distribute as long as they cite the primary source of publication.

The Rev Cubana Estomatol is subject to the Creative Commons Attribution-Non-Commercial 4.0 International License (CC BY-NC 4.0) and follows the publication model of SciELO Publishing Schema (SciELO PS) for publication in XML format.

You are free to:

  • Share — copy and redistribute the material in any medium or format.
  • Adapt — remix, transform, and build upon the material.

The licensor cannot revoke these freedoms as long as you follow the license terms.

Under the following terms:

No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.

Notices:

  • You do not have to comply with the license for elements of the material in the public domain or where your use is permitted by an applicable exception or limitation.
  • No warranties are given. The license may not give you all of the permissions necessary for your intended use. For example, other rights such as publicity, privacy, or moral rights may limit how you use the material.