Hyaluronic Acid as an Adjunct to Chlorhexidine Mouthwash in Managing Gingivitis: Randomized Clinical Trial
Keywords:
mouthwashes; patient satisfaction; gingivitis; taste alterationAbstract
Introduction: Gingivitis is one of the most common periodontal diseases. Chlorhexidine represents one of the most frequently used mouthwashes. Hyaluronic acid has anti-inflammatory, anti-edematous and antimicrobial effects beside improved tissue healing. The combined effect of the two mouthwashes was not investigated before.
Objective: To explore the efficacy of the use hyaluronic acid (HYL) mouthwash as adjunct to Chlorhexidine (CHX) mouthwash compared to Chlorhexidine mouthwash alone in gingivitis patients.
Methods: Sixteen gingivitis patients were randomly assigned to either control group (receiving CHX) or test group (receiving HYL+CHX) after supragingival scaling was performed. Clinical parameters (bleeding on probing (BoP) and plaque index (PI)) and patient-reported outcomes were assessed at baseline and seven days post-operatively.
Results: Intragroup analysis showed significant improvement of BoP (p-value= 0.014 for each; intervention and control) and of PI p-value=0.014 for each; intervention and control); but they failed to reach significant level in intergroup analysis (BoP=0.57; PI=0.96). Post-operative questionnaire revealed non-significant results.
Conclusions: Adding HYL to CHX showed comparable results to CHX alone regarding reduction of bleeding on probing and plaque index.
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Copyright (c) 2026 Heba Samir, Ayat Gamal-AbdelNaser, Mohamed Osama, Mohamed Kamal, AbdELRahman AbdelAtty, Areej Ahmed, Amira Khaled, Doaa Abdelmonaim, Rania Ahmed, Marwa Elsayed
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