Relationship between Diabetes Mellitus type II and Apical Periodontitis
Keywords:
diabetes mellitus, periodontitis apical, revisión sistemáticaAbstract
Introduction: the relationship between Diabetes Mellitus type II and Apical Periodontitis has not yet been fully clarified; understanding this relationship can contribute to more effective clinical management of the patient in endodontics. This work seeks to answer the following question: Is there a relationship between Diabetes Mellitus type II and Apical Periodontitis?
Objective: to identify by reviewing the literature if there is a relationship between Diabetes Mellitus type II and Apical Periodontitis.
Methods: in the month of June 2024, the Pubmed/Medline electronic database was used to carry out a literature search applying the formula ((Diabetes Mellitus, Type 2) OR (Diabetes Mellitus)) AND (Periapical Periodontitis) originated from keywords and Boolean operators. Only human studies, in English, published between January 2019 and May 2024 were included. Two reviewers independently conducted the search, a third reviewer acted as referee. The PRISMA recommendations were considered in the development of the review.
Results: a total of 16 articles were included, of which 13 report a relationship between Diabetes Mellitus type II and Apical Periodontitis, while in the remaining 3 no association was found between these two pathologies.
Conclusion: under the conditions of the present systematic review of the literature, it is concluded that there is a relationship between Diabetes Mellitus type II and Apical Periodontitis. Multidisciplinary management is important to promote glycemic control in diabetic patients to prevent complications in their oral health.
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References
Gardner DG, Shoback D. Greenspan endocrinología básica y clínica 10ma edición. McGraw Hill; 2018.
Organización Panamericana de la Salud. Panorama de la diabetes en la región de las Américas. Organización Panamericana de la Salud; 2023.
Berbudi A, Rahmadika N, Tjahjadi AI, Ruslami R. Type 2 Diabetes and its Impact on the Immune System. Curr Diabetes Rev. 2020;16(5):442-449. DOI: https://doi.org/10.2174/1573399815666191024085838
Owen K, Turner H, Wass J. Oxford handbook of endocrinology and diabetes 4th edition. Oxford University Press; 2022.
Sperling MA, Majzoub JA, Menon RK, Stratakis, CA. Sperling pediatric endocrinology 5th edition. Elsevier; 2020.
Ahmad R, Haque M. Oral Health Messiers: Diabetes Mellitus Relevance. Diabetes Metab Syndr Obes. 2021 Jul 1;14:3001-3015. DOI: https://doi.org/10.2147/dmso.s318972
Cervino G, Terranova A, Briguglio F, De Stefano R, Famà F, D'Amico C, Amoroso G, Marino S, Gorassini F, Mastroieni R, Scoglio C, Catalano F, Lauritano F, Matarese M, Lo Giudice R, Nastro Siniscalchi E, Fiorillo L. Diabetes: Oral Health Related Quality of Life and Oral Alterations. Biomed Res Int. 2019 Mar 18;2019:5907195. DOI: https://doi.org/10.1155/2019/5907195
DeFronzo RA, Ferrannini E, Zimmet P, Alberti G. International textbook of diabetes mellitus 4th edition. John Wiley & Sons; 2015.
Monnier L, Colette C. Diabetología 3ra edición. Elsevier; 2020.
Sánchez Delgado JA, Sánchez Lara NE. Epidemiología de la diabetes mellitus tipo 2 y sus complicaciones. Rev. Finlay [Internet]. 2022 Jun [citado 2024 Nov 04] ; 12( 2 ): 168-176. Disponible en: https://revfinlay.sld.cu/index.php/finlay/article/view/1121
Castellanos JL, Díaz LM, Lee, EA. Medicina en odontología: manejo dental de pacientes con enfermedades sistémicas. Editorial El Manual Moderno; 2015.
Lerman I. Atención integral del paciente diabético 4ta edición. McGraw Hill; 2011.
Morales JA. Diabetes 3ra edición. Universidad Autónoma del Estado de Hidalgo; 2013.
Verhulst MJL, Loos BG, Gerdes VEA, Teeuw WJ. Evaluating All Potential Oral Complications of Diabetes Mellitus. Front Endocrinol (Lausanne). 2019 Feb 18;10:56. DOI: https://doi.org/10.3389/fendo.2019.00056
Graunaite I, Lodiene G, Maciulskiene V. Pathogenesis of apical periodontitis: a literature review. J Oral Maxillofac Res. 2012 Jan 1;2(4):e1. DOI: https://doi.org/10.5037/jomr.2011.2401
Tibúrcio-Machado CS, Michelon C, Zanatta FB, Gomes MS, Marin JA, Bier CA. The global prevalence of apical periodontitis: a systematic review and meta-analysis. Int Endod J. 2021 May;54(5):712-735. DOI: https://doi.org/10.1111/iej.13467
Sisli SN. Evaluation of the relationship between type II diabetes mellitus and the prevalence of apical periodontitis in root-filled teeth using cone beam computed tomography: an observational cross-sectional study. Med Princ Pract. 2019;28(6):533-538. DOI: https://doi.org/10.1159/000500472
Pérez-Losada FL, López-López J, Martín-González J, Jané-Salas E, Segura-Egea JJ, Estrugo-Devesa A. Periodontitis apical y control glucémico en pacientes diabéticos tipo 2: estudio transversal. J Clin Exp Dent. 2020;12(10) :e964 –e971. DOI: https://doi.org/10.4317/jced.57191
Saleh W, Xue W, Katz J. Diabetes mellitus and periapical abscess: a cross-sectional study. J Endod. 2020;46(11):1605-1609. DOI: https://doi.org/10.1016/j.joen.2020.08.015
Sarmento EB, Gomes CC, Pires FR, Pinto LC, Antunes LAA, Armada L. Inmunoexpresión de biomarcadores de resorción ósea en periodontitis apical en diabéticos y normoglucémicos. Int Endod J. 2020;53(8):1025–1032. DOI: https://doi.org/10.1111/iej.13305
Juncar RI, Precup AI, Juncar M. Lesiones inflamatorias odontogénicas en pacientes con diabetes mellitus tipo 2: un estudio prospectivo de 128 casos. Niger J Clin Pract. 2020;23(3):298–303. DOI: https://doi.org/10.4103/njcp.njcp_112_19
De la Torre-Luna R, Domínguez-Pérez RA, Guillén-Nepita AL, Ayala-Herrera JL, Martínez-Martínez RE, Romero-Ayala ME, et al. Prevalencia de Candida albicans en infecciones endodónticas primarias asociada con una mayor frecuencia de periodontitis apical en pacientes con diabetes mellitus tipo dos. Eur J Clin Microbiol Infect Dis. 2020;39(1): DOI: https://doi.org/10.1007/s10096-019-03702-z
Yip N, Liu C, Wu D, Fouad AF. The association of apical periodontitis and type 2 diabetes mellitus: a large hospital network cross-sectional case-controlled study. J Am Dent Assoc. 2021;152(6):434-443. DOI: https://doi.org/10.1016/j.adaj.2021.01.005
Uğur Aydın Z, Ocak MG, Bayrak S, Göller Bulut D, Orhan K. The effect of type 2 diabetes mellitus on changes in the fractal dimension of periapical lesion in teeth after root canal treatment: a fractal analysis study. Int Endod J. 2021;54(2):181–189. DOI: https://doi.org/10.1111/iej.13409
Heikkilä P, Niskanen L, But A, Sorsa T, Haukka J. Oral health associated with incident diabetes but not other chronic diseases: a register-based cohort study. Front Oral Health. 2022;3:956072. DOI: https://doi.org/10.3389/froh.2022.956072
Loureiro C, Buzalaf MAR, Pessan JP, Ventura TMO, Pelá VT, Ribeiro APF, et al. Proteomic analysis of infected root canals with apical periodontitis in patients with type 2 diabetes mellitus: a cross-sectional study. Int Endod J. 2022;55(9):910–922. DOI: https://doi.org/10.1111/iej.13794
Stys LPA, Böttcher DE, Scarparo RK, Gonçalves Waltrick SB, de Figueiredo JAP, Gomes MS, et al. Serum levels of inflammatory markers and HbA1c in patients with type 2 diabetes and apical periodontitis: preliminary findings. Aust Endod J. 2022;48(1):105–115. DOI: https://doi.org/10.1111/aej.12569
Aldoss A, Alghofaily M, Alsalleeh F. Bacterial quantity and interleukin-17 expression in necrotic teeth with apical periodontitis from type II diabetic patients. Int Endod J. 2023;56(7):881-895. DOI: https://doi.org/10.1111/iej.13927
Camponogara JG, de Ferreira TGM, Pelissari TR, Anversa AM, Moreira CHC, Bier CAS. Demographics, smoking status, and systemic health factors associated with apical periodontitis in a Brazilian rural population: a cross-sectional study. Clin Oral Investig. 2023;27(12):7319–7325. DOI: https://doi.org/10.1007/s00784-023-05322-6
Wang S, Wang X, Bai F, Shi X, Zhou T, Li F. Effect of endodontic treatment on clinical outcome in type 2 diabetic patients with apical periodontitis. Heliyon. 2023;9(3):e13914. DOI: https://doi.org/10.1016/j.heliyon.2023.e13914
Paljević E, Brekalo Pršo I, Vidas Hrstić J, Božac E, Pezelj-Ribarić S, Peršić Bukmir R. Healing of apical periodontitis in type II diabetes mellitus patients: a prospective study. Oral Dis. 2024;30(5):3422–3430. https://doi.org/10.1111/odi.14772
Borgo Sarmento E, Helena Teixeira de Lima Ribeiro Andrade R, Cristina Gomes C, Ramôa Pires F, Bastos Valente MI, Mafra Moreno A, Orsini M, Carvalho Ferreira D, Souza Gonçalves L, Armada L. Proinflammatory cytokine expression in apical periodontitis from diabetic patients. Int J Dent. 2023;2023:4961827. DOI: https://doi.org/10.1155/2023/4961827
Vázquez-Ramos VR, Pérez-Serrano RM, García-Solís P, Solís-Sainz JC, Espinosa-Cristóbal LF, Castro-Ruíz JE, Domínguez-Pérez RA. Root canal microbiota as an augmented reservoir of antimicrobial resistance genes in type 2 diabetes mellitus patients. J Appl Oral Sci. 2023;30:e20220362. DOI: https://doi.org/10.1590/1678-7757-2022-0362
Davidović B, Krunić J, Mladenović I, Stojanović N, Hannig M, Vitkov L. Effects of apical periodontitis treatment on hyperglycaemia in diabetes: a prospective cohort study. Int Endod J. 2024;57(8):1099-1109. DOI: https://doi.org/10.1111/iej.14068
PradeepKumar AR, JothiLatha S, Durvasulu A, Muralidhar L, Vimalesh Alagu J, Shereen J, Kishen A. Impact of type 2 diabetes mellitus on the occurrence of vertical root fracture: a case-control study. J Endod. 2024;50(4):450-455.e1. DOI: https://doi.org/10.1016/j.joen.2024.01.006
Ceriello A, Prattichizzo F. Variability of risk factors and diabetes complications. Cardiovasc Diabetol. 2021;20(1):101. DOI: https://doi.org/10.1186/s12933-021-01289-4
Davies TF. A case-based guide to clinical endocrinology. Totowa: Humana Press; 2008.
Medina-Chávez JH, Vázquez-Parrodi M, Santoyo-Gómez DL, Azuela-Antuna J, Garnica-Cuellar JC, Herrera-Landero A, Balandrán-Duarte DA. Protocolo de atención integral: complicaciones crónicas de diabetes mellitus 2. Rev Med Inst Mex Seguro Soc. 2022;60(Supl 1):S19-33. Disponible en: https://www.imbiomed.com.mx/articulo.php?id=117377
Orrego A, Vélez H, Rojas W, Borrero J, Restrepo J. Fundamentos de medicina: endocrinología. 7a ed. Medellín: Corporación para Investigaciones Biológicas; 2012.
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