Pleomorphic adenoma mimicking oral lipoma

Authors

  • Janaina Santos Universidade Federal do Rio Grande do Norte, Departamento de Odontologia, Programa de Pós-graduação em Ciências Odontológicas. Natal, Brasil. https://orcid.org/0000-0002-8939-0839
  • Rani Gonçalo Universidade Federal do Rio Grande do Norte, Departamento de Odontologia, Programa de Pós-graduação em Ciências Odontológicas. Natal, Brasil. https://orcid.org/0000-0002-6762-135X
  • José Santos Universidade Federal do Rio Grande do Norte, Departamento de Odontologia, Programa de Pós-graduação em Ciências Odontológicas. Natal, Brasil. https://orcid.org/0000-0002-2584-2381
  • Marcelo Silveira Universidade Federal do Rio Grande do Norte, Departamento de Odontologia, Programa de Pós-graduação em Ciências Odontológicas. Natal, Brasil. https://orcid.org/0000-0002-8628-0570
  • Lélia Queiroz Universidade Federal do Rio Grande do Norte, Departamento de Odontologia, Programa de Pós-graduação em Ciências Odontológicas. Natal, Brasil. https://orcid.org/0000-0003-3380-0226

Keywords:

pleomorphic adenoma, oral medicine, minor salivary glands.

Abstract

Introduction: Pleomorphic adenoma is the most common benign salivary gland neoplasm. It may affect major and minor salivary glands. It presents at a broad age range and is characterized by great clinical and pathological variability and high recurrence rates. Objective: Describe a case of pleomorphic adenoma, with emphasis on clinical and pathological aspects, differential diagnosis and clinical management. Case report: A male 72-year-old patient presents with a well-defined nodular lesion in the lower section of the left maxillary groove with a time of evolution of four years. Excisional biopsy was performed. The diagnostic hypotheses considered were lymphoid hyperplasia, pleomorphic adenoma and lipoma, with greater attention to the latter, due to the fact that it floated in formaldehyde. Microscopic examination revealed proliferation of epithelial and myoepithelial cells amidst a variable stroma. Thus, a histopathological diagnosis of pleomorphic adenoma was issued. Conclusion: The present study highlights the importance of careful histopathological examination to rule out other diagnostic hypotheses and malignant neoplasms. Next, clinical and microscopic findings will lead to an accurate diagnosis indispensable to adopt an appropriate therapeutic approach.

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References

Reinheimer A, Vieira DS, Cordeiro MM, Rivero ER. Retrospective study of 124 cases of salivary gland tumors and literature review. J Clin Exp Dent. 2019;11(11):e1025-32. DOI: https://doi.org/10.4317/jced.55685

Mahomed Y, Meer S. Primary Epithelial Minor Salivary Gland Tumors in South Africa: A 20-Year Review. Head Neck Pathol. 2019;14:715-23. DOI: https://doi.org/10.1007/s12105-019-01111-4

El-Naggar AK, Chan JKC, Grandis JR, Takata T, Slootweg PJ. WHO Classification of Head and Neck Tumours. 4th ed. Lyon: IARC Press; 2017.

Liao WC, Chih-Cha C, Ma H, Hsu CY. Salivary Gland Tumors: A Clinicopathologic Analysis from Taipei Veterans General Hospital. Ann Plast Surg. 2020;84(1S):S26-S33. DOI: https://doi.org/10.1097/SAP.0000000000002178

Pérez-de-Oliveira ME, Leonel ACLDS, de Castro JFL, Carvalho EJA, Vargas PA, Perez DEDC. Histopathological Findings of Intraoral Pleomorphic Adenomas: A Retrospective Study of a Case Series. Int J Surg Pathol. 2019;27(7):729-35. DOI: https://doi.org/10.1177/1066896919854181

Bhatia JSS. Pleomorphic Adenoma of Upper Lip: A Rare Case Presentation. Indian J Otolaryngol Head Neck Surg. 2019;71(Suppl 1):755-8. DOI: https://doi.org/10.1007/s12070-018-1537-7

Nourwali I, Dar-Odeh N. Pleomorphic Adenoma in the Lower Lip: A Case Report and a Review. Eur J Dent. 2019;13(4):649-53. DOI: https://doi.org/10.1055/s-0039-1700363

Raman S, Sherlin HJ. Utility of smooth muscle actin and CD117 as reliable markers in the diagnosis of salivary gland neoplasms. J Oral Maxillofac Pathol. 2019;23(2):218-23. DOI: https://doi.org/10.4103/jomfp.JOMFP_225_18

Soares AB, de Araújo VC, Juliano PB, Altemani A. Angiogenic and lymphangiogenic microvessel density in recurrent pleomorphicadenoma. J Oral Pathol Med. 2009;38(8):623-9. DOI: https://doi.org/10.1111/j.1600-0714.2009.00794.x

Soares AB, Demasi APD, Altemani A, de Araújo VC. Increased mucin 1 expression in recurrence and malignant transformation of salivary gland pleomorphic adenoma. Histopathology. 2011;58(3):377-82. DOI: https://doi.org/10.1111/j.1365-2559.2011.03758.x

Wang YL, Zhu YX, Chen TZ, Wang Y, Sun GH, Zhang L, et al. Clinicopathologic study of 1176 salivary gland tumors in a Chinese population: experience of one cancer center 1997-2007. Acta Otolaryngol. 2012;132(8):879-86. DOI: https://doi.org/10.3109/00016489.2012.662715

Speight PM, Barrett AW. Salivary gland tumours. Oral Dis. 2002;8(5):229‐40. DOI: https://doi.org/10.1034/j.1601-0825.2002.02870.x

Pires FR, Pringle GA, de Almeida OP, Chen SY. Intra-oral minor salivary gland tumors: a clinicopathological study of 546 cases. Oral Oncol. 2007;43:463-70. DOI: https://doi.org/10.1016/j.oraloncology.2006.04.008

Nonitha S, Yogesh TL, Nandaprasad S, Maheshwari BU, Mahalakshmi IP, Veerabasavaiah BT. Histomorphological comparison of pleomorphic adenoma in major and minor salivary glands of oral cavity: A comparative study. J Oral Maxillofac Pathol. 2019;23(3):356. DOI: https://doi.org/10.4103/jomfp.JOMFP_91_19

Katabi N, Xu B, Jungbluth AA, Zhang L, Shao SY, Lane J, et al. PLAG1 immunohistochemistry is a sensitive marker for pleomorphic adenoma: a comparative study with PLAG1 genetic abnormalities. Histopathology. 2018;72(2):285-93. DOI: https://doi.org/10.1111/his.13341

Chen AM, Garcia J, Bucci MK, Quivey JM, Eisele DW. Recurrent pleomorphic adenoma of the parotid gland: long-term outcome of patients treated with radiation therapy. Int J Radiat Oncol Biol Phys. 2006;66:1031-5. DOI: https://doi.org/10.1016/j.ijrobp.2006.06.036

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Published

2020-11-27

How to Cite

1.
Santos J, Gonçalo R, Santos J, Silveira M, Queiroz L. Pleomorphic adenoma mimicking oral lipoma. Rev Cubana Estomatol [Internet]. 2020 Nov. 27 [cited 2025 Feb. 7];58(1):e3304. Available from: https://revestomatologia.sld.cu/index.php/est/article/view/3304

Issue

Vol. 58 No. 1 (2021): JAN- MAR

Section

Case Report

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