Kaposi sarcoma in late HIV/AIDS diagnosis

Authors

Keywords:

Kaposi sarcoma, human immunodeficiency virus, acquired immunodeficiency syndrome, Mexico.

Abstract

Introduction: Kaposi sarcoma is a multifocal malignant neoplasm of endothelial cells which presents with characteristic lesions on the skin, mouth and lymph glands.

Objective: Describe a case of Kaposi sarcoma with characteristics that hindered HIV infection diagnosis.

Case presentation: A case is presented of a male 30-year-old patient recently diagnosed with acquired immunodeficiency syndrome, and not following any treatment. The patient was referred to the maxillofacial surgery service for right cervical adenopathy biopsy. Physical examination revealed generalized edema in both lower limbs, with hyperpigmented lesions of macular and papular appearance and various shades of color. A purplish pigmented lesion was detected in the hard palate mucosa. The lesion covered the palatal midline and extended toward the left hemiarch. Exeresis of the adenopathy was performed for diagnostic purposes, confirming the diagnosis of Kaposi sarcoma.

Conclusions: Lack of familiarity with the clinical characteristics of Kaposi sarcoma, and not performing a biopsy of the skin lesions and a complete examination of the oral cavity, made the neoplasm go unnoticed to routine medical tests, leading to low suspicion of HIV/AIDS infection and delaying timely treatment. In advanced immunosuppression, Kaposi sarcoma related to acquired immunodeficiency syndrome tends to be more aggressive.

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Author Biographies

Carlos Guillermo Camacho Olguín, Clínica de Cirugía de Cabeza, Cuello y Maxilofacial. Pachuca de Soto, México.

Egresado de la Facultad de Ciencias Medicas de la UAEH . Diplomado por la UNAM / CIORE en Implantología General y Rehabilitación, y en Relaciones interpersonales y Filosofía Existencial Enfocada al Desarrollo Humano por la SEP.

Especialista en Primer Grado de Cirugía Maxilofacial en el Hospital Universitario General Calixto Garcia.

Grado Médico en Cirugía Oncológica de Cabeza y Cuello en el Instituto de Oncología Y Radiobiología de La Habana

Certificado por el Consejo Mexicano de Cirugía Oral y Maxilofacial.

Las principales líneas de investigación: Neoplasias de Cabeza y Cuello, y Trauma Maxilofacial.

Mario Alberto Lagunes López, Clínica de Cirugía Rino-Facial. Puebla, México.

Alta Especialidad en Medicina en Cirugía Rino-Máxilo-Facial2015-2016 | Hospital Ángeles de Puebla/UNAMGalardonado con el premio “Mario Scarrone” por la ALACIBU en el cono norte como el residente más distinguido, obteniendo la más alta calificación en evaluación curricular en Latinoamérica Especialidad en Cirugía Oral y Maxilofacial2011-2015 | Hospital Regional 1° de Octubre ISSSTE/UNAMGraduado con mención honorífica hospitalaria y universitaria.Certificado por el Consejo Mexicano de Cirugía Oral y Maxilofacial, obteniendo el 1er lugar nacional en los exámenes de certificación. Licenciatura en Estomatología 2004-2010 | BUAP

Juan David Jímenez Salazar, Hospital Universitario “General Calixto García”, Servicio de Cirugía Maxilofacial. La Habana, Cuba.

Universidad de Ciencias Medicas de La Habana: La Habana, La Habana, CU
ACCOMF: MEDELLIN , ANTIOQUIA , COAO FOUNDATION LA: BOGOTA , COLOMBIA , CO

References

México. Secretaría de Salud, Centro Nacional para la Prevención y el Control del VIH y el sida, Dirección General de Epidemiología. Vigilancia epidemiológica de casos de VIH/sida en México. Registro Nacional de Casos de sida. Actualización al 3er. trimestre del 2019. 2019. [acceso 05/02/2020]. Disponible en: https://www.gob.mx/cms/uploads/attachment/file/513719/RN_3erTrim_2019.pdf

Hwang JP, Granwehr BP, Torres HA, Suarez-Almazor ME, Giordano TP, Barbo AG, et al. HIV testing in patients with cancer at the initiation of therapy at a large US comprehensive cancer center. J Oncol Pract. 2015;11:384-90. PMID: 26243649

Li J, Thompson TD, Tai E, Zhao G, Oster AM. Testing for human immunodeficiency virus among cancer survivors under age 65 in the United States. Prev Chronic Dis.. 2014 [acceso 05/02/2020];11:E200. PMID: https://pubmed.ncbi.nlm.nih.gov/25393748/

Yarchoan R, Uldrick TS. HIV-Associated Cancers and Related Diseases. N Engl J Med. 2018 [acceso 05/02/2020]; 378 (11):1029-1041. PMCID: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6890231/

Robbins HA, Shiels MS, Pfeiffer RM, Engels EA. Epidemiologic contributions to recent cancer trends among HIV-infected people in the United States. AIDS. 2014;28(6):881-90. PMID: 24300545

México. Gobierno de México, Secretaría de Salud, Centro Nacional para la Prevención y el Control del VIH y el sida. Día mundial del sida. 2019. [acceso 20/02/2020]. Disponible en: https://www.gob.mx/cms/uploads/attachment/file/513718/BOLETIN_D_A_MUNDIAL_28_NOV_VFIN.pdf

Cornejo P, Cavildo D, Volkow P. Non-AIDS defining cancer (NADC) among HIV-infected patients at an oncology tertiary-care center in Mexico. AIDS Res Ther. 2018;15(1):16. PMID: 30368240

Cañas-Ruano E, Martín-Castillo M, Raventós B, Burgos J, Curran A, Navarro J, et al. Incidence of malignancy in a Spanish cohort of patients infected by the human immunodeficiency virus. Med Clin (Barc). 2020;155(7):288-94. PMID: 32005558

Chang Y, Cesarman E, Pessin MS, Lee F, Culpepper J, Knowles DM, et al. Identification of Herpesvirus-Like DNA Sequences in AIDS-associated Kaposi's Sarcoma. Science. 1994;1266:1865-9. PMID: 7997879

Florek A, Eilers D, Armstrong A. A case of Kaposi sarcoma in an immunocompetent, heterosexual Irish man: a discussion of etiology and viral transmission. Dermatol Online J. 2015;21(10). PMID: 26632797

Antman K, Chang Y. Kaposi's sarcoma. N Engl J Med. 2000;342(14):1027-38. PMID: 10749966

Cesarman E, Damania B, Krown SE, Martin J, Bower M, Whitby D. Kaposi sarcoma. Nat Rev Dis Primers. 2019;62(6):730-8. PMCID: PMC6685213

Forrestel A, Naujokas A, Martin J, Maurer T, McCalmont T, Laker-Opwonya M, et al. Bacillary angiomatosis masquerading as Kaposi's sarcoma in East Africa. J Int Assoc Provid AIDS Care. 2015;14(1):21-5. PMID: 24718378

Giudice G, Paciel D, Vola M, Agorio C. Co-infección Sarcoma de Kaposi - Histoplasmosis en una paciente con VIH. 16.º Congreso Uruguayo de Dermatología 16-20 Oct 2018. Montevideo; 2019. [acceso 09/02/2020]. Disponible en: http://www.infectologia.edu.uy/produccion-cientifica/congresos/2018/co-infeccion-sarcoma-de-kaposi-histoplasmosis-en-una-paciente-con-vih

Katano H. Pathological Features of Kaposi's Sarcoma-Associated Herpesvirus Infection. Adv Exp Med Biol. 2018;1045:357-76. PMID: 29896675

Cacciari V, Arra A, D’Alessandro D, Errea S, Kohan D, Elsner B, et al. Enfermedad de Castleman e infección por HIV. Presentación de dos casos y revisión de la literatura. Acta SIDA Infec. 2015 [acceso 09/02/2020]; 23(88):33-41. Disponible en: https://infectologia.info/wp-content/uploads/2016/07/ASEI-88-2.pdf

Rodríguez L, Mahaht G, Salazar L, Magola. Sarcoma de Kaposi y enfermedad de Castleman multicéntrica VHH-8 positivo - VIH Negativo. Acta Med Colomb. 2018;43(1):30-2. DOI: https://doi.org/10.36104/amc.2018.1357

Krown S, Testa M, Huang J. AIDS-related Kaposi's Sarcoma: Prospective Validation of the AIDS Clinical Trials Group Staging Classification. AIDS Clinical Trials Group Oncology Committee. J Clin Oncol. 1997;15:3085-92. PMID: 9294471

Maya A, Segovia S, Madrigal S, Abrego I, Salas J. Sarcoma de Kaposi en región oral y maxilofacial, una neoplasia olvidada. Rev Esp Cir Oral Maxilofac. 2018 [acceso 10/02/2020]; 40(1):22-6. Disponible en: https://www.sciencedirect.com/science/article/pii/S1130055817300060?via%3Dihub

Volkow P, Cesarman G, Garciadiego P, Rojas E, Cornejo P. Clinical characteristics, predictors of immune reconstitution inflammatory syndrome and long-term prognosis in patients with Kaposi sarcoma. AIDS Res Ther. 2017;14(1):30. PMID: 28558783

Berretta M, Martellotta F, Di Francia R, Spina M, Vaccher E, Balestreri L. Clinical presentation and outcome of non-AIDS defining cancers, in HIV-infected patients in the ART-era: The Italian Cooperative Group on AIDS and tumors activity. Eur Rev Med Pharmacol Sci. 2015;19(19):3619-34. PMID: 26502852

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Published

2022-01-01

How to Cite

1.
Camacho Olguín CG, Lagunes López MA, Jímenez Salazar JD, Padovani Clemente S. Kaposi sarcoma in late HIV/AIDS diagnosis. Rev Cubana Estomatol [Internet]. 2022 Jan. 1 [cited 2025 Apr. 14];59(1):e3200. Available from: https://revestomatologia.sld.cu/index.php/est/article/view/3200

Issue

Vol. 59 No. 1 (2022): JAN- MAR

Section

Case Report

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