Hypodontia and accessory navicular bone: an interesting syndromic association
Keywords:
hypodontia, accessory navicular bone, PAX9, syndrome.Abstract
Teeth are developed from many interactions between oral epithelium and mesenchymal cells. A number of genes are involved in tooth development, as well as in other organs, and upper and lower limbs. PAX9, a member of thetranscriptional factor family, is one of the main drivers of this development, playing
a key role in dental hypodontia and malformations in the lower limb bones. The aim
of this report was to present the association between hypodontia and the accessory
navicular bone based on a case report. This is a 18 years old female patient, who
attended a dental clinic because she had acute pain in the 3.6 tooth and also pain
on the left foot's inner area. The radiographic examination showed loss of the teeth
1.7, 2.7, 2.8, 3.8 and 4.8; and the presence of an accessory navicular bone in the
left foot. It is interesting to suggest that this rare association, with clear dominant
autosomal inheritance, might exist; since the dental agenesis and the presence of
accessory navicular bone have similar prevalence, which could point to a new
syndromic association probably related to the lack of PAX9.
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