Histopathological relation of epithelial dysplasia to p53 oncoprotein in oral leukoplakia
Keywords:
Oral leukoplakia, epithelial dysplasia, p53 oncoprotein.Abstract
The oral leukoplasia is a well known precancerous injury due to its association withthe presence of epithelial dysplasia and its trend to malignant transformation. To
eliminate the subjectivity in the determination of the epithelial dysplasia degrees,
biological markers have been used among them the AcM.antip53 Thus, authors
assessed the expression of AcM antip53 in the different degrees of epithelial
dysplasia in the oral leukoplasia. Biopsies from 46 patients diagnosed with oral
leukoplasia were used from the Oral Pathology Department of the Stomatology
Faculty of La Habana. Samples were processed by the paraffin-inclusion technique
and stained with immunohistochemical technique of the avidin-biotin-peroxidase
complex for the AcM p53. The correlation between the immunoassay pattern for
p53 and the degree of epithelial dysplasia was studied. It was demonstrated that
there is a significant association between the immunostain of basal and supra-basal
cells of epithelium with the p53 oncoprotein in the different degrees of severity of
the epithelial dysplasia, which could be related to the progressive increase of the
observed cellular atypia. We concluded that in the study samples there was a
coincident relation of the increase in the degree of severity of the epithelial
dysplasia, with the marking of the p53 oncoprotein. These evidences suggested
that the immunohistochemical analysis of p53 overall with the histological
parameters mainly those related to the degree of severity of the epithelial dysplasia
could be used to made a more accurate diagnosis and to contribute to prevention of
oral cancer.
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