Histological alterations caused by Venezuelan chewing tobacco (Chimó) present in periodontal tissues in rats
Keywords:
Effects/gingival, tobacco/chew, chimó/ nicotineAbstract
Chimó is a tobacco derivative used in Venezuela containing nicotine. Itsharmlessness has been questionated due to potential damages on periodontal
tissues. Aim of present research was to study histological alterations that chimó
could causes on periodontal tissues in Wistar rats. Twelve male Wistar rats were
selected, 12 were the control group and 12 the experimental one. Control group
received physiologic solution and the experimental one received chimó in a dosage
of 18g/5cc (chimó/physiologic solution) to both groups by topical via (rubbing).
Application frequency: three days/week during 20 weeks. In control group there
was not changes. Experimental group showed Orthokeratosis (54 %), slight
epithelial dysplasia (45 %), granulocytes, hyperkeratosis, acanthosis, fibrosis, and
stroma collagen disease and chronic inflammation (19 %), and a moderate
dysplasia (10 %). We conclude that histological changes seen are directly related to
chimó exposure time.
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