Oral Burkitt's lymphoma associated with human immunodeficiency virus

Authors

  • Rafaela Maia Cardoso Almendra Department of Dentistry. "Professor Edgard Santos" Hospital, Federal University of Bahia-UFBA, Salvador, BA
  • Graziele Beanes da Silva Santos Department of Dentistry. "Professor Edgard Santos" Hospital, Federal University of Bahia-UFBA, Salvador, BA
  • Natália Nascimento Odilon Department of Dentistry. "Professor Edgard Santos" Hospital, Federal University of Bahia-UFBA, Salvador, BA
  • Leonardo Francisco Provedel de Souza Department of Dentistry. "Professor Edgard Santos" Hospital, Federal University of Bahia-UFBA, Salvador, BA
  • Viviane Almeida Sarmento Department of Dentistry. "Professor Edgard Santos" Hospital, Federal University of Bahia-UFBA, Salvador, BA
  • Luiza Cavalcante Fadul Department of Anatomic Pathology. "Professor Edgard Santos" Hospital, Federal University of Bahia, BA
  • Luciano Espinheira Fonseca Júnior Department of Anatomic Pathology. "Professor Edgard Santos" Hospital, Federal University of Bahia, BA

Keywords:

Burkitt's lymphoma, mouth neoplasms, HIV.

Abstract

Introduction: Burkitt's lymphoma is an aggressive form of B cell lymphoma generally diagnosed in children and young adults. This tumor has three variants: African (endemic), American (sporadic), and immunodeficiency-associated.
Objective: present a case of Burkitt's lymphoma that manifested as a tumor mass in the upper right maxillary region of a patient with AIDS treated at Professor Edgar Santos University Hospital in Salvador, Bahia, Brazil.
Clinical case: a male 20-year-old HIV-positive patient was referred from another hospital with a possible odontogenic infection that persisted after drainage and antibiotic therapy. The patient presented a tumor growth in the upper right gingival mucosa. After biopsy, histopathological findings were suggestive of Burkitt's lymphoma. An immunohistochemical panel was positive for CD20 and Bcl6 and negative for CD3, Bcl2, and terminal deoxynucleotidyl transferase antibodies. The Ki67 expression level was 80 %. The final diagnosis was immunodeficiency-associated Burkitt's lymphoma. The patient was successfully treated with cytoreductive chemotherapy (cyclophosphamide, doxorubicin, vincristine, and prednisone), followed by high-dose methotrexate, cyclophosphamide, doxorubicin and vincristine, alternating with high-dose cytarabine, ifosfamide and etoposide. No signs of recurrence have been noted during the follow-up period.
Conclusions: Burkitt's lymphoma is an aggressive neoplasia with a rapidly progressing clinical course. Therefore, differential diagnosis from other benign oral diseases is of great importance.

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Author Biographies

Rafaela Maia Cardoso Almendra, Department of Dentistry. "Professor Edgard Santos" Hospital, Federal University of Bahia-UFBA, Salvador, BA

Department of Dentistry. Professor Edgard Santos Hospital, Federal University of Bahia–UFBA, Salvador, BA, Brazil. 

Rua Augusto Viana, s/n – Canela – CEP: 40.110-060 -Salvador, Bahia, Brazil. Phone number e FAX: +55 (71) 3283-8140.

RMCA: Dentist and Master´s degree in progress in Faculty of Medical Sciences of Campinas State University, Campinas, São Paulo, Brazil. 

Phone number: (+55)(71)99152-1869

Rafaela contributed to the acquisition of data, writing and review of the manuscript. Responsible for manuscript submission.

Graziele Beanes da Silva Santos, Department of Dentistry. "Professor Edgard Santos" Hospital, Federal University of Bahia-UFBA, Salvador, BA

Department of Dentistry. Professor Edgard Santos Hospital, Federal University of Bahia–UFBA, Salvador, BA, Brazil. 

GBSS: Resident, Clinical Hospital of the Faculty of Medicine, University of São Paulo, São Paulo, Brazil. 

Phone number: (+55)(71)98840-6838

Graziele contributed to the acquisition of data, writing and review of the manuscript. 

Natália Nascimento Odilon, Department of Dentistry. "Professor Edgard Santos" Hospital, Federal University of Bahia-UFBA, Salvador, BA

Department of Dentistry. Professor Edgard Santos Hospital, Federal University of Bahia–UFBA, Salvador, BA, Brazil. 

NNO: Resident, Professor Edgard Santos Hospital, Federal University of Bahia, Salvador, Bahia, Brazil. 

Phone number: (+55)(73)99123-7968

Natália contributed to the acquisition of data and writing of the manuscript.  

Leonardo Francisco Provedel de Souza, Department of Dentistry. "Professor Edgard Santos" Hospital, Federal University of Bahia-UFBA, Salvador, BA

Department of Dentistry. Professor Edgard Santos Hospital, Federal University of Bahia–UFBA, Salvador, BA, Brazil. 

LFPS: Dentist, Professor Edgard Santos Hospital, Federal University of Bahia, Salvador, Bahia, Brazil. 

Phone number(+55)(71)98123-9820

Leonardo contributed to the acquisition of data and writing of the manuscript. Formatted the images to insert in the article.

Viviane Almeida Sarmento, Department of Dentistry. "Professor Edgard Santos" Hospital, Federal University of Bahia-UFBA, Salvador, BA

Department of Dentistry. Professor Edgard Santos Hospital, Federal University of Bahia–UFBA, Salvador, BA, Brazil. 

VAS: Dentist, Professor Edgard Santos Hospital, Federal University of Bahia, Salvador, Bahia, Brazil. 

Phone number: (+55)(71)99118-5054

Viviane contributed to the acquisition of data and writing of the manuscript. Described the images of computed tomography.

Luiza Cavalcante Fadul, Department of Anatomic Pathology. "Professor Edgard Santos" Hospital, Federal University of Bahia, BA

Department of Anatomic Pathology. Professor Edgard Santos Hospital, Federal University of Bahia, BA, Brazil.

LCF: Resident, Anatomic Pathology at Professor Edgard Santos Hospital, Federal University of Bahia, Bahia, Brazil and Master's degree in Human Pathology, FIOCRUZ/ Federal University of Bahia, Salvador, Bahia, Brazil. 

Phone number: (+55)(71)99133-7073

Luiza contributed to the writing and review of the manuscript. Luiza assisted with immunohistochemical staining and diagnosis,  as well as the description of the results.

Luciano Espinheira Fonseca Júnior, Department of Anatomic Pathology. "Professor Edgard Santos" Hospital, Federal University of Bahia, BA

Department of Anatomic Pathology. Professor Edgard Santos Hospital, Federal University of Bahia, BA, Brazil.

LEFJ: Assistant Professor, Federal University of Bahia; Department of Pathology, Professor Edgard Santos Hospital, Federal University of Bahia, Salvador, Bahia, Brazil. 

Phone number: (+55)(71)99133-7073

Luciano contributed assisted with immunohistochemical staining and diagnosis, as well as the description of the results.

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Published

2017-06-07

How to Cite

1.
Almendra RMC, Santos GB da S, Odilon NN, de Souza LFP, Sarmento VA, Fadul LC, et al. Oral Burkitt’s lymphoma associated with human immunodeficiency virus. Rev Cubana Estomatol [Internet]. 2017 Jun. 7 [cited 2025 Feb. 18];54(2):45-50. Available from: https://revestomatologia.sld.cu/index.php/est/article/view/1358

Issue

Vol. 54 No. 2 (2017): APR- JUN

Section

Case Report

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