Efecto de los antibióticos pediátricos sobre la microdureza superficial del esmalte dental en dientes bovinos
Resumen
Objetivo: Comparar el efecto de antibióticos pediátricos sobre la microdureza superficial del esmalte dental en dientes bovinos.
Métodos: Se realizó un estudio in vitro en 60 dientes bovinos no cariados. Se sumergieron 15 dientes en cada grupo de cuatro soluciones (amoxicilina, amoxicilina + ácido clavulánico, eritromicina y saliva artificial) durante 1 minuto tres veces al día durante 7 y 14 días. Se midió la microdureza de la superficie del esmalte al inicio, a los7 y 14 días de exposición a los antibióticos.
Resultados: La microdureza superficial del esmalte de los dientes de los grupos de antibióticos pediátricos se redujo después de 7 y 14 días de exposición con diferencia significativa (p < 0,001), respecto a la microdureza inicial. Además, en el grupo expuesto a saliva artificial no hubo diferencia significativa (p = 0,097) en los diferentes tiempos de evaluación.
Conclusiones: Se concluye que los antibióticos pediátricos afectan la microdureza del esmalte, siendo la eritromicina la que mayor disminución generó a los 14 días de exposición.
Palabras clave
Referencias
World Health Organization. Antimicrobial resistance. Philippines: WHO;2019 [acceso 23/04/2023]. Disponible en: https://apps.who.int/iris/handle/10665/163468
Messina F, Clavenna A, Cartabia M, Piovani D, Bortolotti A, Fortino I, et al. Antibiotic prescription in the outpatient paediatric population attending emergency departments in Lombardy, Italy: a retrospective database review. BMJ Paediatr Open. 2019;3(1):e000546. DOI: https://doi.org/10.1136/bmjpo-2019-000546
Li G, Jackson C, Bielicki J, Ellis S, Hsia Y, Sharland M. Global sales of oral antibiotics formulated for children. Bull World Health Organ. 2020;98(7):458-66. DOI: https://doi.org/10.2471/BLT.19.235309
Angarita-Díaz MDP, Bernal-Cepeda L, Rodríguez-Paz M, Vergara-Mercado M, Herrera-Herrera A, Forero-Escobar D, et al. Prescribing antibiotics by dentists in Colombia: Toward a conscientious prescription. J Public Health Dent. 2021;81(2):100-12. DOI: https://doi.org/10.1111/jphd.12416
Llanos-Zavalaga R. Prescripción de antibióticos en consulta externa pediátrica de un hospital de Lima, Perú. Rev Peru Med Exp Salud Pública. 2004 [acceso 23/04/2023];20(1):28-36. Disponible en: http://www.scielo.org.pe/scielo.php?script=sci_arttext&pid=S1726-46342004000100006&lng=es
Siddiq H, Pentapati KC, Shenoy R, Velayutham A, Acharya S. Evaluation of Sugar Content and Erosive Potential of the Commonly Prescribed Liquid Oral Medications. Pesqui Bras Odontopediatria Clin Integr 2020;20:e5025. DOI: https://doi.org/10.1590/pboci.2020.023
Coutinho LS, Sande ACMN, Nunes NNV, Oliveira RS, Campos EJ. Cariogenic and erosive potential of pediatric medicines and vitamin supplements. Rev Odontol UNESP. 2022;51:e20220006. DOI: https://doi.org/10.1590/1807-2577.00622
Al Humaid J. Sweetener content and cariogenic potential of pediatric oral medications: A literature. Int J Health Sci (Qassim). 2018[acceso 23/04/2023];12(3):75-82. Disponible en: https://pubmed.ncbi.nlm.nih.gov/29896075/
Mahmoud E, Omar O. Erosive and cariogenic potential of various pediatric liquid medicaments on primary tooth enamel: A SEM study. Dent Med Probl 2018;55:247-54. DOI: https://doi.org/10.17219/dmp/91539
Hodge HC, McKay H. The Microhardness of Teeth. JADA. 1933;20:227. DOI: https://doi.org/10.14219/jada.archive.1933.0047
Passos VF, Melo MAS, Park J, Strassler HE. Current Concepts and Best Evidence on Strategies to Prevent Dental Erosion. Compend Contin Educ Dent 2019;40:80-6. Disponible en: https://pubmed.ncbi.nlm.nih.gov/30767547/
Ebrahimiramezani S, Pahlevani Z, Khosravi Z, Moslehi S. Evaluation of Cariogenic Potential of Commenly Used Oral Supplements on Childrens Deciduous Teeth. Pajouhan Scientific Journal. 2023;21(1):15-21. DOI: https://doi.org/10.52547/psj.21.1.15
Kulkarni P, Anand A, Bansal A, Jain A, Tiwari U, Agrawal S. Erosive effects of pediatric liquid medicinal syrups on primary enamel: An in vitro comparative study. Indian J Dent. 2016;7(3):131-3. DOI: https://doi.org/10.4103/0975-962X.189338
Yun I-G, Chung K-H. Effects of commercial dry syrups on tooth surfaces. J Korean Acad Oral Heal. 2019;43:78. DOI: https://doi.org/10.11149/jkaoh.2019.43.2.78
Rocha CT, Nogueira ASB, Almeida J de A, Rodrígues LKA, Neves BG. Erosive Effect of Analgesics on Primary Tooth Enamel-An in Vitro Study. Pesqui Bras Odontopediatria Clín Integr. 2022;22:e210149. DOI: https://doi.org/10.1590/pboci.2022.066
Gutiérrez J, Mendoza R, Mauricio F, Munive-Degregori A, Alvitez-Temoche D, Mayta-Tovalino F. Comparison of the Microhardness of Surface Enamel Exposed to Anti-asthmatic Inhalants. J Contemp Dent Pract. 2022;23(2):149-53. DOI: http://dx.doi.org/10.5005/jp-journals-10024-3295
Scatena C, Galafassi D, Gomes-Silva JM, Borsatto MC, Serra MC. In Vitro Erosive Effect of Pediatric Medicines on Deciduous Tooth Enamel. Braz Dent J 2014;25:22-7. DOI: https://doi.org/10.1590/0103-6440201302344
Paolone G, Scolavino S, Gherlone E, Spagnuolo G. Direct Esthetic Composite Restorations in Anterior Teeth: Managing Symmetry Strategies. Symmetry (Basel). 2021;13(5):797. DOI: https://doi.org/10.3390/sym13050797
Yılmaz N, Baygin O, Cakıroglu TN, Tüzüner T, Deger O. In vitro evaluation of the effects of frequently prescribed pediatric drugs on the microhardness of permanent tooth enamel. Dent Med Probl. 2019;56:131-6. DOI: https://doi.org/10.17219/dmp/105562
Mali GV, Dodamani AS, Karibasappa GN, Kumar PV, Jain VM. Effect of conventional and sugar free pediatric syrup formulations on primary tooth enamel hardness: An in vitro study. J Indian Soc Pedod Prev Dent. 2015;33(4):331. DOI: https://doi.org/10.4103/0970-4388.165707
Bardis S, Gehan G, Amr M. Evaluation of the Erosive Effect of Chewing Aspocid versus its Soluble Form on Micro Hardness of Primary Teeth Enamel in Heart Disease Children. (In Vitro-Study). Int J Dentistry Oral Sci. 2019;6(3):681-4. DOI: https://doi.org/10.19070/2377-8075-19000134
Reyes C, Chávez G. Efecto de los medicamentos pediátricos sobre la microdureza superficial del esmalte de dientes diciduos. Kiru. 2006 [acceso 23/04/2023];3(1):19-23. Disponible en: https://hdl.handle.net/20.500.12727/1686
Cavalcanti AL, De Sousa RI, Clementino MA, Vieira FF, Cavalcanti CL, Xavier AF. In vitro analysis of the cariogenic and erosive potential of paediatric antitussive liquid oral medications. Tanzan J Health Res. 2012;14:139-45. DOI: https://doi.org/10.4314/thrb.v14i2.7
Almutairi M, Moussa I, Alsaeri N, Alqahtani A, Alsulaiman S, Alhajri M. The Effects of Different Pediatric Drugs and Brushing on the Color Stability of Esthetic Restorative Materials Used in Pediatric Dentistry: An In Vitro Study. Children (Basel). 2022;9(7):1026. DOI: https://doi.org/10.3390/children9071026
Vinitha A, Korath A, Ektah K, Arun J, ElzaT. Pediatric syrups: a risk to enamel microhardness? Annals and Essences of Dentistry. 2017;9(4). DOI: https://doi.org/10.5368/aedj.2017.9.4.1.2
Baglar S, Erdem U, Dogan M, Turkoz M. Dentinal tubule occluding capability of nano-hydroxyapatite; The in-vitro evaluation. Microsc Res Tech. 2018;81(8):843-54. DOI: https://doi.org/10.1002/jemt.23046
Álvarez M, García JA. Eritromicina. Descubrimiento, características y aplicaciones. Revista de la oficina de farmacia. 2002 [acceso 23/05/2023];21(2):78-82. Disponible en: https://www.elsevier.es/es-revista-offarm-4-articulo-eritromicina-descubrimiento-caracteristicas-aplicaciones-13026500
Huttner A, Bielicki J, Clements M, Frimodt-Møller N, Muller A, Paccaud JP, et al. Oral amoxicillin and amoxicillin-clavulanate: properties, indications, and usage. Clinical Microbiology and Infection. 2019;26(7):871-9. DOI: https://doi.org/10.1016/j.cmi.2019.11.028
Abou Neel EA, Aljabo A, Strange A, Ibrahim S, Coathup M, Young AM, et al. Demineralization–remineralization dynamics in teeth and bone. Int J Nanomedicine. 2016;19(11):4743-63. DOI: https://doi.org/10.2147%2FIJN.S107624
Foong LK, Foroughi MM, Mirhosseini AF, Safaei M, Jahani S, Mostafavi M, et al. Applications of nano-materials in diverse dentistry regimes. RSC Adv. 2020;10(26):15430-60. DOI: https://doi.org/10.1039/D0RA00762E
Kushneet S, Mohit K, Dileep S. Insight into the amoxicillin resistance, ecotoxicity, and remediation strategies. J. Water Process. Eng. 2021;39(6):101858. DOI: https://doi.org/10.1016/j.jwpe.2020.101858